Genetic sequencing suggests Italian "patient zero" may be infected in Germany

 

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Genetic sequencing suggests Italian "patient zero" may be infected in Germany

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On March 11, a media reported that a research team in Milan, believed that Italy ’s first novel coronavirus pneumonia patient might be transmitted through Germany, rather than directly from China. Because some studies have shown that the genetic sequencing of the new coronavirus strain that appeared earlier in Italy currently matches the genetic sequencing of that in a case that appeared in Germany in January.

According to a Reuters report on March 11, since the first case of new coronavirus pneumonia was found in Lombardy in northern Italy on February 21, scientists have been searching for the "patient zero" in Italy. Although Milan's research team has not yet fully identified the "patient zero", but by sequencing the genes of an earlier coronavirus, it found that the virus matches the coronavirus gene sequence of a case that appeared in Germany in January.

"The gene sequence closest to an earlier virus in Italy came from a case infected in Munich, Germany, from about January 19 to January 22," said Massimo, head of the infectious disease research team at Milan Sacco Hospital.” Massimo Galli said. The earlier viruses tested were considered to be the "ancestors" of all viruses in Italy.

Gurry also added that the German patient was infected with the virus after coming into contact with a person from China.

Galli said that his research team's analysis showed that the new coronavirus pneumonia epidemic had already appeared in Italy as early as January 25-26, which was faster than the time when the first patient in Italy was officially diagnosed in the northern city of Codogno.

"We can imagine a person (" Patient Zero ") contacting an infected person in Munich and then to Italy. This person spread the virus‘ without any symptoms ’in Italy.” Gurry said.

Italian doctors initially believed that the first patient in Kodano was infected by a colleague who returned from China, but the colleague's test result was negative, indicating that the person returning from China was not a "patient zero."

Sequencing and  

On January 24, 2020, the French Ministry of Health confirmed the first three cases of patients affected by the Wuhan coronavirus. On January 29, 2020, the Institut Pasteur, which is responsible for monitoring respiratory viruses in France, sequenced the whole genome of the coronavirus known as "2019-nCoV" (SARS-CoV-2), becoming the first institution in Europe to sequence the virus since the start of the outbreak. The virus was sequenced at the Institut Pasteur's Mutualized Platform for Microbiology (P2M), which performs genome sequencing on bacterial, viral, fungal and parasite strains received by National Reference Centers and World Health Organization Collaborating Centers for the purpose of infectious disease surveillance.

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